Lee K, Paulk AC, Ro YG, Cleary DR, Tonsfeldt KJ, Kfir Y, Pezaris JS, Tchoe Y, Lee J, Bourhis AM, Vatsyayan R, Martin JR, Russman SM, Yang JC, Baohan A, Richardson RM, Williams ZM, Fried SI, Hoi Sang U, Raslan AM, Ben-Haim S, Halgren E, Cash SS, Dayeh SA.
Nature Communications: https://www.nature.com/articles/s41467-023-43727-9
PMID: 38233418
DOI: 10.1038/s41467-023-43727-9
Press release:
Video:
Abstract: Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.