MGH
HMS
Neurology
Thier Research Bldg.
Room 415.
50 Blossom Street
Boston, MA 02114
Tel: (617) 726-3888
Welcome to the Fried Lab

Articles

Lee, SW & Fallegger, F & Casse BDF & Fried, SI
Implantable microcoils for intracortical magnetic stimulation.
Sci. Adv. (2016) Dec 9;2(12):e1600889. doi: 10.1126/sciadv.1600889.
PMID: 27957537  | Abstract  

Lee, SW & Fried, SI
Enhanced control of cortical pyramidal neurons with micromagnetic stimulation.
IEEE Trans. Neural. Syst. Rehabil. Eng. (2016) Nov 22;[Epub ahead of print] doi: 10.1109/TNSRE.2016.2631446.
PMID: 27893396  | Abstract  

Im, M & Fried, SI
Directionally selective retinal ganglion cells suppress luminance responses during natural viewing.
Sci. Rep. (2016) Oct 19;35708(6):1-9. doi: 10.1038/srep35708.
PMID: 27759086  | Abstract  

Im, M & Fried, SI
Indirect activation elicits strong correlations between light and electrical responses in ON but not OFF retinal ganglion cells.
J. Physiol. (2015) Aug 15;593(16):3577-96. doi: 10.1113/JP270606.
PMID: 26033477  | Abstract  

Twyford, P & Fried, SI
The Retinal Response to Sinusoidal Electrical Stimulation.
IEEE Trans. Neural. Syst. Rehabil. Eng. (2015) Apr [Epub ahead of print] doi: 10.1109/TNSRE.2015.2415811.
PMID: 25850091  | Abstract  

Lee, SW & Fried, SI
Suppression of subthalamic nucleus activity by micromagnetic stimulation.
IEEE Trans. Neural. Syst. Rehabil. Eng. (2015) Jan 1;23(1):116-127. doi: 10.1109/TNSRE.2014.2348415.
PMID: 25163063  | Abstract  

Twyford, P, Cai, C, & Fried, SI
Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells.
J. Neural Eng. (2014) Apr 1;11(2):025001. doi: 10.1088/1741-2560/11/2/025001
PMID: 24556536  | Abstract  

Cai, C, Twyford, P, & Fried, SI
The response of retinal neurons to high-frequency stimulation.
J. Neural Eng. (2013) Jun 1;10(3):036009. doi:10.1088/1741-2560/10/3/036009
PMID: 23594620  | Abstract  

Lee, SW, Eddington, DK, & Fried, SI
Responses to pulsatile subretinal electric stimulation: effects of amplitude and duration.
J. Neurophysiol. (2013) Apr 1;109(7):1954-1968. doi: 10.​1152/​jn.​00293.​2012
PMID: 23343891  | Abstract  

Fang, Y, Cho, KS, Tchedre, K, Lee, SW, Guo, C, Kinouchi, H, Fried, SI, Sun, X, & Chen, DF
Ephrin-A3 Suppresses Wnt Signaling to Control Retinal Stem Cell Potency.
Stem Cells. (2013) Feb 12;31(2):349-359. doi: 10.1002/stem.1283.
PMID: 23165658  | Abstract  

Bonmassar, G*, Lee, SW*, Freeman, DK, Polasek, M, Fried, SI†, & Gale, JT
Microscopic magnetic stimulation of neural tissue.
Nat. Commun. (2012) Jun 26;3:921. doi: 10.1038/ncomms1914.
PMID: 22735449  | Abstract  

Freeman, DK, Jeng, J, Kelly, SK, Hartveit, E, & Fried, SI
Calcium channel dynamics limit synaptic release in response to prosthetic stimulation with sinusoidal waveforms – a computational study.
J. Neural Eng. (2011) May 31;8(4):046005.
PMID: 21628768  | Abstract  |  PDF

Freeman, DK, Rizzo, JF & Fried, SI
Encoding Visual Information in Retinal Ganglion Cells with Prosthetic Stimulation.
J. Neural Eng. (2011) Jun;8(3):035005.
PMID: 21593546  | Abstract  |  PDF

Jeng, J, Tang, S, Molnar, A, Desai, NJ & Fried, SI
The sodium channel band shapes the response to electric stimulation in retinal ganglion cells.
J Neural Eng. (2011) Jun;8(3):036022.
PMID: 21558602  | Abstract  |  PDF

Cai, C, Ren, Q, Desai, NJ, Rizzo, JF & Fried, SI
Response variability to high rates of electric stimulation in retinal ganglion cells.
J. Neurophysiology (2011) Jul;106(1):153-62.
PMID: 21490287  | Abstract  |  PDF

Freeman, DK & Fried, SI
Multiple components of ganglion cell desensitization in response to prosthetic stimulation.
J Neural Eng. (2011) Jan 19;8(1):016008.
PMID: 21248379  | Abstract  |  PDF

Freeman, DK, Eddington, DK, Rizzo, JF & Fried, SI
Selective Activation of Neuronal Targets with Sinusoidal Electric Stimulation.
J Neurophys. (2010) Nov;104(5):2778-91.
PMID: 20810683  | Abstract  |  PDF

Freeman, DK, Rizzo, JF & Fried, SI
Electric Stimulation with Sinusoids and White Noise for Neural Prostheses
Front. Neuropro. (2010) doi:10.3389/neuro.20.001-4.
PMID: 20582268  | Abstract  |  PDF

Fried SI, Lasker AC, Desai NJ, Eddington DK & Rizzo JF (2009).
Axonal sodium channel bands shape the response to electric stimulation in retinal ganglion cells.
Fried SI, Lasker AC, Desai NJ, Eddington DK & Rizzo JF (2009).
J.Neurophys. (2009) Apr 101(4):1972-87
PMID: 19193771  | Abstract  |  PDF

Fried SI, & Masland, RH.
Image processing: How the retina detects the direction of image motion.
Curr. Biol. (2007) Jan 23;17(2):R63-6
PMID: 17240332  | Abstract  |  PDF

Fried SI, Hsueh HA & Werblin FS.
A method for generating precise temporal patterns of retinal spiking using prosthetic devices.
J. Neurophys (2006) Feb (95):970-8
PMID: 16236780  | Abstract  |  PDF

Fried SI, Münch TA & Werblin FS.
Directional selectivity is formed at multiple levels by laterally offset inhibition in the rabbit retina.
Neuron (2005) Apr 7;46(1):117-27
PMID: 15820698  | Abstract  |  PDF

Fried SI, Münch TA & Werblin FS.
Mechanisms and circuitry underlying directional selectivity in the retina.
Nature (2002) Nov 28;420(6914):411-4.
Featured in: News and Views
PMID: 12459782  | Abstract  |  PDF

Neuroscience: How neurons compute direction
Nature – News and Views (2002) Nov 28;420(6914):375-6
Sterling, P.
PMID: 12459772

Gaumond RP & Fried SI.
Analysis of cat multi-channel acoustic brain-stem response data using dipole localization methods.
Electro. & Clin. Neurophys. (1986) Apr; 63(4):376-83
PMID: 2419096  | Abstract   |  PDF


Book chapters

Fried SI, Hsueh HA & Werblin FS (2007). Generating precise patterns of retinal spiking. Proceedings of the 2nd Annual Dept. of Energy (DOE) Conference on Retinal Prosthetics, Ft. Lauderdale, Florida (USA).

Fried SI & Jensen RJ, (2011). Electric stimulation of the retina: the contribution of animal studies Retinal Prosthetics, G. Dagnelie, Ed., Springer.

Conference Proceedings

Fried SI & Werblin FS (2004). Electrical stimulation elicits complex response patterns in the retina. Proceedings of the International Joint Conference on Retinal Prosthetics, Budapest. (Hungary).

Fried SI, Hsueh HA & Werblin (2005). Generating precise temporal patterns of retinal spiking using prosthetic devices. Proceedings of the 10th Annual International Functional Electrical Stimulation Society, Montreal, Quebec (Canada).

Fried SI & Werblin FS (2006). Targeting specific ganglion cell types with prosthetic stimulation. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Wyatt, JL., Eisenman,A, Valavanis,S, Fried,S, Stasheff,S & Rizzo, JF. (2007). A Likelihood Method for Estimating Visual Motion Parameters From Retinal Ganglion Cell Responses. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Fried SI, Lasker, A, Eddington, DK & Rizzo, JF (2007). Individual retinal ganglion cell sub-types respond differently to electric stimulation. BioMedical Engineering Society Annual Meeting, Los Angeles, CA.

Wyatt,JL, Valavanis,S, Wu,YC, Nemati,S, Eisenman,A, Fried,S, Stasheff,S & Rizzo, JF (2008). A Likelihood Method for Estimating Visual Motion Parameters From Retinal Ganglion Cell Responses. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Drohan W, Wyatt, JL, Kelly, SK, Fried, SI & Rizzo,JF (2008). External Field Firing Thresholds for Neurons Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Lasker,A, Desai,NJ, Rizzo,JF, Koizium,A & Fried, SI (2008). The size and location of the spike initiation zone is variable in rabbit retinal ganglion cells. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Fried SI, Lasker, A, Desai, NJ, Eddington, DK & Rizzo, JF (2008). Two different sections of rabbit ganglion cell axon are activated by electric stimulation. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Jeng J, Desai, NJ, Rizzo, JF & Fried SI (2009). Effects of Variations in the Dense Sodium Channel Band in Retinal Ganglion Cells. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Fried SI, Desai, NJ, Eddington, DK & Rizzo, JF (2009). The Distribution of Voltage Across the Proximal Axon Underlies Spike Initiation in Response to Electric Stimulation of Retinal Ganglion Cells. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Desai, NJ, Eddington, DK, Rizzo, JF & Fried SI (2009). Differences in Sodium Channel Bands Underlie Different Responses to Electrical Stimulation in Retinal Ganglion Cells. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Desai, NJ, Rizzo, JF, Fried SI & Cai, C (2010). Sodium Channel Band Properties Contribute to Activation Threshold Variability. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Jeng J, Rizzo, JF & Fried SI (2010). Sodium Channel Band Properties Contribute to Activation Threshold Variability. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Fried SI , Cai, C, Rizzo, JF & Q. Ren (2010). High Frequency Electric Stimulation of Retinal Neurons Elicits Physiological Signaling Patterns. Biomedical Engineering Society Annual Meeting, Austin, TX.

Freeman, DK, Rizzo, JF & Fried SI (2011). Selective Activation of Retinal Neurons with Sinusoidal Electric Stimulation. Biomedical Engineering Society Annual Meeting, Austin, TX.

Cai, C, Ren, Q & Fried SI (2011). Two Classes of Action Potentials are Initiated by Electric Stimulation of Retinal Ganglion Cells. Biomedical Engineering Society Annual Meeting, Austin, TX.

Fried SI, Cai, C, Ren, Q & Rizzo, JF (2011). Factors Affecting the Reliability by Which Spikes are Generated in Response to High Rates of Stimulation. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Freeman, DK & Fried SI (2011). Ganglion Cell Desensitization to Repetitive Stimulation Correlates with Brightness Fading in Human Subjects. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Jeng J, Freeman, DK, Kelly, SK & Fried SI (2011). Ca Channel Kinetics Underlie the Low Frequency Sensitivity of Bipolar Cells. Association for Vision in Research and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.